Transcript Diapozitiv 1

Od nevrolaboratorija do klinične nevrologije
primer: nevroplastičnost
fajko.bajrovic@mf.uni-lj.si
Nervous system
- diffuse neural network
Camillo Golgi (1843-1926)
“diffuse neural network”
Nervous system
- neural doctrine
Ramon y Cajal (1852-1934)
“neural doctrine”
Nervous system
- synapse
Sir CS Sherrington (1857–1952)
“synapse”
Nervous system
- plastic, reverberating neural network
“plastic, reverberating neural networks”
DO Hebb (1904-1985)
Activity and brain development
Blakemore and Cooper (Nature, 1970)
Mehanizem nevroplastičnosti
• Modifikacija sinaptičnega prenašanja
• Nove sinapse
– Kolateralno brstenje
– Nevroneogeneza
DiAntonio, (2000)
DiAntonio, (2000)
Gage et al. (Nat Med. 1998)
Somatotopičnost
Wilder Penfield (1891-1976)
Somatotopičnost
mechanisms of neuronal circuit development :
-activity-dependent (Hebb)
-activity-independent (Sperry)
Sperry vs. Hebb (chemoaffinity)
Dufour et al. (Neuron, 2003)
Sperry vs. Hebb (activity)
Knudsen (Nature, 2002)
Activity and trophic feedback
Purves (Nature, 1988)
Nevroplastičnost
Trojan and Pokorny (Physiol Res, 1999)
Nevroplastičnost
Trojan and Pokorny (Physiol Res, 1999)
Nevroplastičnost
Trojan and Pokorny (1999)
Trojan and Pokorny (Physiol Res, 1999)
Nevroplastičnost
Trojan and Pokorny (1999)
Trojan and Pokorny (Physiol Res, 1999)
Nevroplastičnost
Trojan and Pokorny (1999)
Trojan and Pokorny (Physiol Res, 1999)
Maguire et al. (Proc Natl Acad Sci U S A, 2000)
Sawaki et al., (Exp Brain Res, 2003)
Nevroplastičnost
• Sposobnost živčevja za reorganizacijo.